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记忆的提取-消退范式对网络游戏成瘾的干预研究
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注册号:

Registration number:

ChiCTR-IPR-17012886 

最近更新日期:

Date of Last Refreshed on:

2017-10-04 

注册时间:

Date of Registration:

2017-10-04 

注册号状态:

预注册  

Registration Status:

Prospective registration  

注册题目:

记忆的提取-消退范式对网络游戏成瘾的干预研究 

Public title:

A Memory Retrieval-Extinction Procedure to Prevent Internet Gaming Disorder 

注册题目简写:

 

English Acronym:

 

研究课题的正式科学名称:

记忆的提取-消退范式对网络游戏渴求的干预效果及其神经机制 

Scientific title:

A Memory Retrieval-Extinction Procedure to Prevent Internet Game Craving and the Underlying Neural Mechanism 

研究课题代号(代码):

Study subject ID:

中科院百人计划(BJ2070000047),国家自然科学基金(31230032,31171083,31471071),安徽省自然科学基金(1208085MH179) 

在二级注册机构或其它机构的注册号:

The registration number of the Partner Registry or other register:

 

申请注册联系人:

张永军 

研究负责人:

张效初 

Applicant:

Yongjun Zhang 

Study leader:

Xiaochu Zhang 

申请注册联系人电话:

Applicant telephone:

+86 15155176033 

研究负责人电话:

Study leader's telephone:

+86 551-63607295 

申请注册联系人传真 :

Applicant Fax:

 

研究负责人传真:

Study leader's fax:

 

申请注册联系人电子邮件:

Applicant E-mail:

andyzhyj@126.com 

研究负责人电子邮件:

Study leader's E-mail:

zxcustc@ustc.edu.cn 

申请单位网址(自愿提供):

Applicant website(voluntary supply):

 

研究负责人网址(自愿提供):

Study leader's website(voluntary supply):

 

申请注册联系人通讯地址:

安徽合肥黄山路443号科大西区生命学院709 

研究负责人通讯地址:

安徽合肥黄山路443号科大西区生命学院709 

Applicant address:

433 Huangshan Road, Hefei, Anhui, China  

Study leader's address:

433 Huangshan Road, Hefei, Anhui, China  

申请注册联系人邮政编码:

Applicant postcode:

 

研究负责人邮政编码:

Study leader's postcode:

 

申请人所在单位:

中国科学技术大学 

Applicant's institution:

University of Science and Technology of China  

是否获伦理委员会批准:

是 

Approved by ethic committee:

Yes 

伦理委员会批件文号:

Approved No. of ethic committee:

2017009 

伦理委员会批件附件:

Approved file of Ethical Committee:

查看附件View

批准本研究的伦理委员会名称:

中国科学技术大学生物医学伦理委员会 

Name of the ethic committee:

Biomedical Ethics Committee of University of Science and Technology of China  

伦理委员会批准日期:

Date of approved by ethic committee:

2013-08-26 

伦理委员会联系人:

 

Contact Name of the ethic committee:

 

伦理委员会联系地址:

 

Contact Address of the ethic committee:

 

伦理委员会联系人电话:

Contact phone of the ethic committee:

 

伦理委员会联系人邮箱:

Contact email of the ethic committee:

 

研究实施负责(组长)单位:

中国科学技术大学 

Primary sponsor:

University of Science and Technology of China  

研究实施负责(组长)单位地址:

安徽合肥黄山路443号 

Primary sponsor's address:

433 Huangshan Road, Hefei, Anhui, China 

试验主办单位(项目批准或申办者):

Secondary sponsor:

国家:

中国

省(直辖市):

安徽

市(区县):

Country:

China

Province:

Anhui

City:

单位(医院):

中国科学技术大学中科院脑功能与脑疾病重点实验室

具体地址:

安徽合肥黄山路443号

Institution
hospital:

CAS Key Laboratory of Brain Function & Disease, University of Science and Technology of China

Address:

433 Huangshan Road, Hefei, Anhui, China

经费或物资来源:

中科院百人计划(BJ2070000047),国家自然科学基金(31230032,31171083,31471071),安徽省自然科学基金(1208085MH179) 

Source(s) of funding:

the 100 Talents Programme of the Chinese Academy of Sciences (BJ2070000047), National Natural Science Foundation of China (31230032,31171083,31471071), Natural Science Foundation of Anhui (1208085MH1) 

研究疾病:

网络游戏障碍 

Target disease:

Internet Gaming Disorder 

研究疾病代码:

 

Target disease code:

 

研究类型:

干预性研究 

Study type:

Interventional study 

研究所处阶段:

探索性研究/预试验 

Study phase:

研究目的:

记忆的提取-消退范式对于物质成瘾的干预已取得一定效果,本研究尝试将该范式应用于非物质成瘾即网络游戏障碍的干预中,探究在记忆的再巩固时间窗内对被试进行记忆的消退训练能否降低其游戏渴求,并揭示这一过程的潜在神经机制。 

Objectives of Study:

The effect of memory retrieval-extinction procedure on substance use diorder intervention has been validated,and we try to apply this procedure to the intervention of Internet gaming disorder, aiming to explore whether the subjects' craving for Internet games can decrease after they receive the memory retrieval-extinction training within memory reconsolidation window. The underlying neural mechanism may also be investigated if the subjects' craving get decreased. 

药物成份或治疗方案详述:

 

Description for medicine or protocol of treatment in detail:

 

研究设计:

随机平行对照 

Study design:

Parallel 

纳入标准:

1.近3个月平均每天玩网络游戏(英雄联盟)3小时以上;2.右利手;3.视力或者矫正视力正常;4.满足DSM-V关于网络游戏障碍的标准5条或以上。 

Inclusion criteria

1. Daily gaming time (LOL)is no less than 3 hours in recent 3 months; 2. Right handed; 3. Normal or corrected to normal vision; 4. Meeting 5 or more criteria of Internet Gaming Disorde in DSM-V. 

排除标准:

1.慢性神经、精神或躯体疾病;2.正接受其他治疗;3.不适应脑电实验;4.其他药物成瘾或非物质成瘾 

Exclusion criteria:

1. Chronic neurological, psychological, or physical diseases; 2. No current usage of psychoactive medication; 3. Not suitable to undergo an EEG experiment; 4. Other drug dependence or non-substance use disorder. 

研究实施时间:

Study execute time:

From2017-11-10To 2018-11-10 

征募观察对象时间:

Recruiting time:

From2017-11-01To 2018-05-01 

干预措施:

Interventions:

组别:

试验组

样本量:

25

Group:

experimental group

Sample size:

干预措施:

在记忆再巩固时间窗内进行游戏相关记忆的消退训练

干预措施代码:

Intervention:

game-related memory extinction training adminstered in memory reconsolidation window

Intervention code:

组别:

对照组

样本量:

25

Group:

control group

Sample size:

干预措施:

在记忆的再巩固时间窗外进行游戏相关记忆的消退训练

干预措施代码:

Intervention:

game-related memory extinction training adminstered out of memory reconsolidation window

Intervention code:

研究实施地点:

Countries of recruitment and research settings:

国家:

中国 

省(直辖市):

安徽 

市(区县):

 

Country:

China 

Province:

Anhui 

City:

 

单位(医院):

中国科学技术大学中科院脑功能与脑疾病重点实验室  

单位级别:

国家级 

Institution
hospital:

CAS Key Laboratory of Brain Function & Disease, University of Science and Technology of China  

Level of the institution:

National Key Laboratory  

测量指标:

Outcomes:

指标中文名:

游戏渴求

指标类型:

主要指标 

Outcome:

game craving

Type:

Primary indicator 

测量时间点:

测量方法:

Measure time point of outcome:

Measure method:

指标中文名:

脑电信号

指标类型:

主要指标 

Outcome:

EEG signal

Type:

Primary indicator 

测量时间点:

测量方法:

Measure time point of outcome:

Measure method:

指标中文名:

心电信号

指标类型:

次要指标 

Outcome:

HR signal

Type:

Secondary indicator 

测量时间点:

测量方法:

Measure time point of outcome:

Measure method:

指标中文名:

皮电信号

指标类型:

次要指标 

Outcome:

GSR signal

Type:

Secondary indicator 

测量时间点:

测量方法:

Measure time point of outcome:

Measure method:

采集人体标本:

Collecting sample(s)
from participants:

征募研究对象情况:

Recruiting status:

正在进行

Recruiting

年龄范围:

Participant age:

最小 Min age 18 years
最大 Max age 25 years

性别:

男女均可

Gender:

Both

随机方法(请说明由何人用什么方法产生随机序列):

电脑程序随机生成随机数进行实验条件顺序的分配

Randomization Procedure (please state who generates the random number sequence and by what method):

Randomly allocate subjects into different orders

盲法:

Blinding:

试验完成后的统计结果(上传文件):

Calculated Results after
the Study Completed(upload file):

是否共享原始数据:

IPD sharing

否No

共享原始数据的方式(说明:请填入公开原始数据日期和方式,如采用网络平台,需填该网络平台名称和网址):

实验全部完成后

The way of sharing IPD”(include metadata and protocol, If use web-based public database, please provide the url):

after experiment

数据采集和管理(说明:数据采集和管理由两部分组成,一为病例记录表(Case Record Form, CRF),二为电子采集和管理系统(Electronic Data Capture, EDC),如ResMan即为一种基于互联网的EDC:

暂定实验服务器

Data collection and Management (A standard data collection and management system include a CRF and an electronic data capture:

tentative lab server

数据与安全监察委员会:

Data and Safety Monitoring Committee:

有/Yes

注册人:

Name of Registration:

 2017-10-04
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